Early studies documented reduced blood group isohaemagglutinins and specific antibody values27,28 with impaired test immunisation responses; however, the concentrations of IgG were such that these findings were not unexpected.View this table:View inlineView popup”In contrast to X linked agammaglobulinaemia and common variable immune deficiency, opportunistic infections associated with disorders of cell mediated immunity commonly occur in Good’s syndrome”A reduced mature B cell count (or even the absence of B cells) was noted in 87% of cases and the absence of pre B cells has been reported in bone marrow samples from patients with Good’s syndrome.29 31 The data on abnormalities in T cell counts and function are limited, although CD4+ T cell lymphopenia and an abnormal CD4+ : CD8+ T cell ratio are seen in large numbers of patients. Studies of cell mediated immunity in Good’s syndrome emphasised that T cell defects, as manifested by cutaneous anergy to two or more test antigens,32,33 or delayed rejection of skin allografts,28,34 were common features of this condition. Overall, 45% of patients have impaired T cell responses to mitogens such as phytohaemagglutinin (PHA).
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average age of Kerala
one thousand infants per Kerala (one Mortality Rate of less than 6) • Presented by the National Family Health Survey (NFHS) 2015-16
Kerala’s infant mortality rates in Russia (8), China (9), Sri Lanka (8 ) And Brazil (15).